.dbdir-page{--dbdir-teal:#5ebabd;--dbdir-blue:#0372b7;--dbdir-ink:#24323a;--dbdir-muted:#5f6f78;--dbdir-line:#313f451f;--dbdir-surface:#fff;--dbdir-line-solid:color-mix(in srgb,#313f45 12%,var(--dbdir-surface));--dbdir-canvas:#f6f9fb;--dbdir-chip-bg:#fff;--dbdir-hero-bg:#313f45;background:var(--dbdir-canvas);color:var(--dbdir-ink)}html[data-theme=dark] .dbdir-page{--dbdir-ink:#e2e8eb;--dbdir-muted:#9fb0b8;--dbdir-line:#6c757d4d;--dbdir-surface:#222d32;--dbdir-line-solid:color-mix(in srgb,#6c757d 30%,var(--dbdir-surface));--dbdir-canvas:#1a2226;--dbdir-chip-bg:#222d32;background:var(--dbdir-canvas)!important}.dbdir-hero{background:var(--dbdir-hero-bg);color:#e8ecef;padding:3.25rem 0 0;position:relative;overflow:hidden}@media (width>=992px){.dbdir-hero{padding:4.5rem 0 0}}html[data-theme=dark] .dbdir-page .dbdir-action code,html[data-theme=dark] .dbdir-page .dbdir-code code{color:inherit!important;background-color:#0000!important}html[data-theme=dark] .dbdir-page{--dbdir-hero-bg:var(--dbdir-canvas)}html[data-theme=dark] .dbdir-hero{padding-bottom:2rem}.dbdir-hero-rain{pointer-events:none;width:100%;height:100%;position:absolute;inset:0}.dbdir-hero>.container{z-index:1;position:relative}@media (width>=1400px){.dbdir-hero>.container{padding-left:13rem!important}}.dbdir-title{color:#e8ecef;letter-spacing:-.5px;user-select:none;margin:1.1rem 0 .9rem;font-size:calc(1.375rem + 1.5vw);font-weight:700;line-height:1.08}html[data-theme=dark] .dbdir-title{color:#b8c4ca!important}@media (width>=1200px){.dbdir-title{font-size:2.6rem}}.dbdir-lead{color:#ffffffa8;user-select:none;margin:0;padding-bottom:2rem;font-size:1.15rem;font-weight:300;line-height:1.5}.dbdir-search-home{margin-top:2rem}.dbdir-search{max-width:40rem;position:relative}.dbdir-search-icon{color:#7d8f98;pointer-events:none;font-size:1.05rem;position:absolute;top:50%;left:1.1rem;transform:translateY(-50%)}.dbdir-search input{color:#24323a;-webkit-appearance:none;appearance:none;background:#fffffff7;border:1px solid #ffffff24;border-radius:6px;width:100%;height:3.25rem;padding:0 4.5rem 0 3rem;font-size:1rem;transition:box-shadow .2s,border-color .2s;box-shadow:0 10px 30px #0000002e}.dbdir-search input::placeholder{color:#8796a0}.dbdir-search input:focus{outline:none;box-shadow:0 10px 30px #0000002e}.dbdir-search input::-webkit-search-cancel-button{display:none}.dbdir-search-kbd,.dbdir-search-clear{position:absolute;top:50%;right:.85rem;transform:translateY(-50%)}.dbdir-search-kbd{color:#6c7a83;pointer-events:none;background:#f4f7f9;border:1px solid #d3dbe0;border-bottom-width:2px;border-radius:4px;padding:.05rem .45rem;font-family:inherit;font-size:.75rem}.dbdir-search.has-value .dbdir-search-kbd,.dbdir-search:focus-within .dbdir-search-kbd{display:none}@media (hover:none){.dbdir-search-kbd{display:none}}.dbdir-search-home .dbdir-search-kbd,html[data-theme=dark] .dbdir-search-kbd{color:#9fb0b8;background:#1f2a30;border-color:#6c757d80}.dbdir-search-clear{color:#6c7a83;cursor:pointer;background:0 0;border:0;padding:.3rem .4rem;font-size:.82rem;display:none}.dbdir-search-clear:hover{color:#24323a}.dbdir-search.has-value .dbdir-search-clear{display:inline-block}.dbdir-search-home .dbdir-search input{background:var(--dbdir-hero-bg);color:#e2e8eb;box-shadow:none;border-color:#6c757d73 #6c757d73 #0000;border-radius:6px 6px 0 0}.dbdir-search-home .dbdir-search input:focus{background:var(--dbdir-hero-bg);box-shadow:none;border-color:#6c757d73 #6c757d73 #0000}html[data-theme=dark] .dbdir-search-home .dbdir-search input,html[data-theme=dark] .dbdir-search-home .dbdir-search input:focus{background:var(--dbdir-hero-bg);box-shadow:none;border-color:#ffffff1a;border-radius:6px}html[data-theme=dark] .dbdir-search-dock .dbdir-search input,html[data-theme=dark] .dbdir-search-dock .dbdir-search input:focus{background:var(--dbdir-surface);color:#e2e8eb}.dbdir-search-home .dbdir-search input::placeholder,html[data-theme=dark] .dbdir-search input::placeholder{color:#8396a0}.dbdir-search-home .dbdir-search-clear{color:#9fb0b8}.dbdir-search-home .dbdir-search-clear:hover{color:#e2e8eb}.dbdir-toolbar{top:var(--mnav-offset,0px);z-index:20;background:color-mix(in srgb,var(--dbdir-canvas)92%,transparent);backdrop-filter:saturate(1.4)blur(10px);border-bottom:1px solid var(--dbdir-line);transition:top .32s cubic-bezier(.33,1,.68,1);position:sticky}.dbdir-page[data-view=indication] .dbdir-toolbar:not(.is-search-docked){backdrop-filter:none;background:var(--dbdir-canvas);position:static;top:auto}.dbdir-search-dock:empty{display:none}.dbdir-search-dock{padding:.8rem 0}.dbdir-toolbar.is-search-docked .dbdir-toolbar-inner{display:none}.dbdir-search-dock .dbdir-search{max-width:none;animation:.18s ease-out dbdirDockIn}.dbdir-search-dock .dbdir-search input{border-color:var(--dbdir-line);height:2.75rem;box-shadow:none}.dbdir-search-dock .dbdir-search input:focus{border-color:var(--dbdir-line);box-shadow:none}@keyframes dbdirDockIn{0%{opacity:0;transform:translateY(-6px)}to{opacity:1;transform:none}}.dbdir-toolbar-inner{align-items:center;gap:.75rem;padding:.8rem 0;display:flex}.dbdir-view{--dbdir-view-pad:3px;isolation:isolate;padding:var(--dbdir-view-pad);border:1px solid var(--dbdir-line);background:color-mix(in srgb,var(--dbdir-muted)8%,var(--dbdir-chip-bg));border-radius:999px;flex:none;grid-template-columns:1fr 1fr;align-items:stretch;display:inline-grid;position:relative}.dbdir-view:before{content:"";top:var(--dbdir-view-pad);bottom:var(--dbdir-view-pad);left:var(--dbdir-view-pad);width:calc(50% - var(--dbdir-view-pad));background:var(--dbdir-chip-bg);border:1px solid color-mix(in srgb,var(--dbdir-muted)45%,var(--dbdir-chip-bg));z-index:0;pointer-events:none;border-radius:999px;transition:transform .28s cubic-bezier(.33,1,.68,1);position:absolute;box-shadow:0 1px 2px #222d3214}.dbdir-view:has([data-view=indication][aria-pressed=true]):before{transform:translate(100%)}html[data-theme=dark] .dbdir-view{background:color-mix(in srgb,var(--dbdir-muted)16%,var(--dbdir-chip-bg))}html[data-theme=dark] .dbdir-view:before{background:color-mix(in srgb,var(--dbdir-muted)28%,var(--dbdir-chip-bg));border-color:color-mix(in srgb,var(--dbdir-muted)55%,var(--dbdir-chip-bg));box-shadow:0 1px 3px #00000047}.dbdir-view button{z-index:1;color:var(--dbdir-muted);cursor:pointer;background:0 0;border:0;border-radius:999px;min-width:6.75rem;padding:.32rem .85rem;font-size:.8rem;font-weight:500;line-height:1.3;transition:color .2s;position:relative}.dbdir-view button:hover,.dbdir-view button[aria-pressed=true]{color:var(--dbdir-ink)}.dbdir-view button:focus-visible{outline:2px solid var(--dbdir-teal);outline-offset:1px}@media (prefers-reduced-motion:reduce){.dbdir-view:before{transition:none}}.dbdir-chips{scrollbar-width:none;flex:auto;gap:.3rem;min-width:0;margin:0;padding:.15rem .1rem;list-style:none;display:flex;overflow-x:auto;-webkit-mask-image:linear-gradient(90deg,#000 calc(100% - 2rem),#0000);mask-image:linear-gradient(90deg,#000 calc(100% - 2rem),#0000)}.dbdir-page[data-view=indication] .dbdir-chips{display:none}.dbdir-page[data-view=indication] .dbdir-toolbar-inner{justify-content:flex-end}.dbdir-chips::-webkit-scrollbar{display:none}@media (width>=1200px){.dbdir-chips{flex-wrap:wrap;overflow:visible;-webkit-mask-image:none;mask-image:none}}.dbdir-chip{white-space:nowrap;border:1px solid var(--dbdir-line);background:var(--dbdir-chip-bg);color:var(--dbdir-ink);cursor:pointer;border-radius:999px;align-items:center;gap:.35rem;padding:.28rem .62rem .28rem .55rem;font-size:.8rem;line-height:1.3;transition:border-color .15s,background-color .15s,color .15s;display:inline-flex}.dbdir-chip:not([aria-pressed=true]):hover{background:color-mix(in srgb,var(--tint,transparent)13%,var(--dbdir-chip-bg));border-color:color-mix(in srgb,var(--tint,var(--dbdir-muted))45%,var(--dbdir-line))}html[data-theme=dark] .dbdir-chip:not([aria-pressed=true]){background:var(--dbdir-canvas);color:var(--dbdir-muted);border-color:#ffffff1a}html[data-theme=dark] .dbdir-chip:not([aria-pressed=true]) .dbdir-chip-count{color:color-mix(in srgb,var(--dbdir-muted)75%,transparent)}html[data-theme=dark] .dbdir-chip:not([aria-pressed=true]):hover{background:color-mix(in srgb,var(--tint,transparent)18%,var(--dbdir-canvas));border-color:color-mix(in srgb,var(--tint,var(--dbdir-muted))45%,#ffffff1a);color:var(--dbdir-ink)}.dbdir-chip:focus-visible{outline:2px solid var(--dbdir-teal);outline-offset:2px}.dbdir-chip-count{color:var(--dbdir-muted);font-variant-numeric:tabular-nums;margin-left:.4rem;font-size:.72rem}.dbdir-chip[aria-pressed=true]{background:color-mix(in srgb,var(--tint,var(--dbdir-muted))22%,var(--dbdir-chip-bg));border-color:color-mix(in srgb,var(--tint,var(--dbdir-muted))65%,var(--dbdir-chip-bg));color:var(--dbdir-ink);font-weight:500}html[data-theme=dark] .dbdir-chip[aria-pressed=true]{background:color-mix(in srgb,var(--tint,var(--dbdir-muted))38%,var(--dbdir-chip-bg));border-color:color-mix(in srgb,var(--tint,var(--dbdir-muted))75%,var(--dbdir-chip-bg))}.dbdir-chip[aria-pressed=true] .dbdir-chip-count{color:var(--dbdir-ink);opacity:.75}.dbdir-body{min-height:60vh;padding:2.25rem 0 4rem}.dbdir-status{color:var(--dbdir-muted);margin:0 0 1.5rem;font-size:.88rem}.dbdir-status strong{color:var(--dbdir-ink);font-weight:600}.dbdir-acc-list{flex-direction:column;gap:.75rem;max-width:54rem;margin:0 auto;display:flex}.dbdir-acc{background:var(--dbdir-surface);border:.5px solid color-mix(in srgb,var(--tint,transparent)20%,var(--dbdir-line));scroll-margin-top:5rem;transition:border-color .15s}.dbdir-acc:has(.dbdir-acc-toggle:hover){border-color:color-mix(in srgb,var(--tint,var(--dbdir-muted))40%,var(--dbdir-line))}.dbdir-acc-head{margin:0}.dbdir-acc-toggle{text-align:left;width:100%;color:var(--dbdir-ink);background:linear-gradient(135deg,color-mix(in srgb,var(--tint,transparent)var(--tint-strong,13%),var(--dbdir-surface))0%,color-mix(in srgb,var(--tint,transparent)var(--tint-soft,3%),var(--dbdir-surface))65%);cursor:pointer;border:0;align-items:center;gap:.75rem;padding:1rem 1.35rem;display:flex}html[data-theme=dark] .dbdir-acc-toggle{--tint-strong:16%;--tint-soft:4%}.dbdir-acc-toggle:focus-visible{outline:2px solid var(--dbdir-teal);outline-offset:2px}.dbdir-acc-title{letter-spacing:-.1px;font-size:1.1rem;font-weight:650;transition:color .15s}.dbdir-acc-toggle:hover .dbdir-acc-title{color:color-mix(in srgb,var(--tint,var(--dbdir-ink))85%,#000)}html[data-theme=dark] .dbdir-acc-toggle:hover .dbdir-acc-title{color:color-mix(in srgb,var(--tint,var(--dbdir-ink))55%,#fff)}.dbdir-acc-count{white-space:nowrap;color:var(--dbdir-muted);font-size:.85rem}.dbdir-acc-chev{color:var(--dbdir-muted);margin-left:auto;font-size:.85rem;transition:transform .25s}.dbdir-acc.is-open .dbdir-acc-chev{transform:rotate(180deg)}.dbdir-acc-panel{grid-template-rows:0fr;transition:grid-template-rows .28s;display:grid}.dbdir-acc.is-open .dbdir-acc-panel{grid-template-rows:1fr}.dbdir-acc-inner{visibility:hidden;min-height:0;transition:visibility 0s linear .28s;overflow:hidden}.dbdir-acc.is-open .dbdir-acc-inner{visibility:visible;transition-delay:0s}.dbdir-acc.is-settled .dbdir-acc-inner{overflow:visible}@media (width>=1200px){.dbdir-acc-list{--dbdir-gap:2rem;--dbdir-link:color-mix(in srgb,var(--dbdir-muted)65%,var(--dbdir-chip-bg));grid-template-columns:15.5rem minmax(0,1fr);grid-template-rows:repeat(var(--n,1),auto)1fr;column-gap:var(--dbdir-gap);border:1px solid var(--dbdir-line);background:var(--dbdir-surface);border-top:0;border-radius:0 0 12px 12px;align-items:start;row-gap:.25rem;max-width:none;margin:0;padding:2rem 2rem 2.25rem;display:grid;position:relative}html[data-theme=dark] .dbdir-acc-list{--dbdir-link:color-mix(in srgb,var(--dbdir-muted)75%,var(--dbdir-chip-bg));background:var(--dbdir-canvas);border-radius:0;padding-top:0}html[data-theme=dark] .dbdir-acc-panel{background:0 0}.dbdir-acc{display:contents}.dbdir-page[data-view=indication] .dbdir-body{padding-top:0}.dbdir-page[data-view=indication] .dbdir-status{padding-top:1.25rem}.dbdir-acc-head{grid-column:1;grid-row:var(--i)}.dbdir-acc-list .dbdir-acc-toggle,html[data-theme=dark] .dbdir-acc-list .dbdir-acc-toggle{background:0 0;border:.5px solid #0000;border-radius:0;padding:.55rem .85rem;position:relative}.dbdir-acc-list .dbdir-acc-toggle:hover,html[data-theme=dark] .dbdir-acc-list .dbdir-acc-toggle:hover{background:color-mix(in srgb,var(--dbdir-muted)8%,transparent)}.dbdir-acc-list .dbdir-acc.is-open .dbdir-acc-toggle{background:color-mix(in srgb,var(--dbdir-muted)12%,var(--dbdir-chip-bg));border-color:#0000}html[data-theme=dark] .dbdir-acc-list .dbdir-acc.is-open .dbdir-acc-toggle{border:1px solid var(--dbdir-line);background:0 0}.dbdir-connector{pointer-events:none;width:100%;height:100%;position:absolute;inset:0;overflow:visible}.dbdir-connector path{fill:none;stroke:var(--dbdir-connector);stroke-width:2px}.dbdir-connector path.is-drawing{stroke-dasharray:var(--len);animation:.28s ease-out dbdirDraw}.dbdir-acc-title{font-size:.95rem;font-weight:600}.dbdir-acc-count{margin-left:auto;font-size:.8rem}.dbdir-acc-unit,.dbdir-acc-chev{display:none}.dbdir-acc-panel{background:var(--dbdir-surface);border:1px solid var(--dbdir-line);grid-area:1/2/-1;transition:none;display:none}.dbdir-acc.is-open .dbdir-acc-panel{animation:.22s ease-out 80ms both dbdirRollOut;display:block}.dbdir-acc-inner,.dbdir-acc.is-open .dbdir-acc-inner{visibility:visible;overflow:visible}.dbdir-acc-panel .dbdir-rows{border-top:0}.dbdir-scroller{overscroll-behavior-y:auto;scrollbar-width:thin;background:var(--dbdir-surface);--dbdir-fade-bg:var(--dbdir-surface);border:0;grid-area:1/2/-1;align-self:stretch;height:0;min-height:max(100%,30rem);position:relative;overflow-y:auto}.dbdir-scroll-fade{z-index:4;pointer-events:none;opacity:0;background:linear-gradient(var(--dbdir-fade-dir,to bottom),color-mix(in srgb,var(--dbdir-fade-bg)92%,transparent),color-mix(in srgb,var(--dbdir-fade-bg)0%,transparent));backdrop-filter:blur(2px);height:2.25rem;-webkit-mask-image:linear-gradient(var(--dbdir-fade-dir,to bottom),#000 30%,transparent);mask-image:linear-gradient(var(--dbdir-fade-dir,to bottom),#000 30%,transparent);transition:opacity .2s;position:sticky}.dbdir-scroll-fade.is-top{margin-bottom:-2.25rem;top:0}.dbdir-scroll-fade.is-bottom{--dbdir-fade-dir:to top;margin-top:-2.25rem;bottom:0}.dbdir-scroller.has-above .dbdir-scroll-fade.is-top,.dbdir-scroller.has-below .dbdir-scroll-fade.is-bottom{opacity:1}html[data-theme=dark] .dbdir-page[data-view=indication] .dbdir-scroller{--dbdir-fade-bg:color-mix(in srgb,#2e86b2 6%,var(--dbdir-surface))}.dbdir-scroller:focus-visible{outline:2px solid var(--dbdir-teal);outline-offset:2px}.dbdir-scroll-group{position:relative}.dbdir-scroller .dbdir-scroll-group.is-current:before{content:"";background:var(--dbdir-bracket);z-index:2;pointer-events:none;border-radius:2px;width:2px;position:absolute;top:0;bottom:0;left:0}.dbdir-acc-list{--dbdir-bracket:color-mix(in srgb,var(--bs-primary)70%,transparent);--dbdir-connector:var(--dbdir-bracket)}html[data-theme=dark] .dbdir-acc-list{--dbdir-bracket:color-mix(in srgb,color-mix(in srgb,var(--bs-primary)65%,#fff)70%,transparent);--dbdir-connector:var(--dbdir-bracket)}.dbdir-scroller .dbdir-row{border-top:.5px solid color-mix(in srgb,var(--dbdir-line)55%,transparent)}.dbdir-scroller .dbdir-scroll-group:first-of-type .dbdir-row:first-child,.dbdir-scroller .dbdir-rows{border-top:0}.dbdir-page .dbdir-scroller .dbdir-row:nth-child(2n){background:0 0}.dbdir-page .dbdir-scroller .dbdir-row.is-alt{background:color-mix(in srgb,var(--dbdir-muted)5%,var(--dbdir-surface))}html[data-theme=dark] .dbdir-page[data-view=indication] .dbdir-scroller .dbdir-row:nth-child(2n){background:0 0}html[data-theme=dark] .dbdir-page[data-view=indication] .dbdir-scroller .dbdir-row.is-alt{background:color-mix(in srgb,var(--dbdir-accent-2)9%,var(--dbdir-surface))}html[data-theme=dark] .dbdir-scroller{background:0 0}}@keyframes dbdirDraw{0%{stroke-dashoffset:var(--len)}to{stroke-dashoffset:0}}@keyframes dbdirRollOut{0%{opacity:0;transform:translate(-10px)}to{opacity:1;transform:none}}.dbdir-rows{border-top:.5px solid color-mix(in srgb,var(--tint,transparent)20%,var(--dbdir-line));margin:0;padding:0;list-style:none}.dbdir-row{grid-template-columns:minmax(0,1fr) 5.25rem 12rem auto;align-items:center;gap:1rem;padding:.75rem 1.35rem;transition:background-color .15s;display:grid;position:relative}.dbdir-row:nth-child(2n){background:color-mix(in srgb,var(--dbdir-muted)5%,var(--dbdir-surface))}html[data-theme=dark] .dbdir-row:nth-child(2n){background:color-mix(in srgb,var(--dbdir-muted)8%,var(--dbdir-surface))}.dbdir-row:has(.dbdir-row-link:focus-visible){outline:2px solid var(--dbdir-teal);outline-offset:-2px}.dbdir-row-main{min-width:0;line-height:1.4}.dbdir-row-link{color:var(--dbdir-ink);font-size:.98rem;font-weight:600;text-decoration:none;transition:color .15s}.dbdir-row-link:after{content:"";z-index:1;position:absolute;inset:0}.dbdir-row-link:focus-visible{outline:none}.dbdir-row-label{color:var(--dbdir-muted);white-space:nowrap;margin-left:.4rem;font-size:.8rem;display:inline-block}.dbdir-row .dbdir-row-trials{justify-self:end;margin:0}.dbdir-row .dbdir-trials strong{color:var(--dbdir-muted);font-weight:500}.dbdir-row .dbdir-copy{justify-self:end;max-width:100%}@media (width<=767.98px){.dbdir-row{grid-template-columns:auto minmax(0,1fr) auto;gap:.5rem .6rem;padding:.85rem 1.1rem}.dbdir-row-main{grid-column:1/-1}.dbdir-row .dbdir-row-trials{justify-self:start}.dbdir-row-label{white-space:normal;margin:.1rem 0 0;display:block}}.dbdir-grid{grid-template-columns:minmax(0,1fr);gap:1rem;display:grid}@media (width>=768px){.dbdir-grid{grid-template-columns:repeat(2,minmax(0,1fr));gap:1.25rem}}@media (width>=1200px){.dbdir-grid{grid-template-columns:repeat(3,minmax(0,1fr))}}@keyframes dbdirFadeIn{0%{opacity:0}to{opacity:1}}.dbdir-page[data-view=size] .dbdir-chip,.dbdir-page[data-view=indication] .dbdir-acc-head{animation:.38s ease-out both dbdirFadeIn;animation-delay:calc(min(var(--i,0),14)*35ms)}.dbdir-page[data-view=indication] .dbdir-scroller .dbdir-row{animation:.4s ease-out both dbdirFadeIn;animation-delay:calc(min(var(--i,0),15)*45ms)}@media (prefers-reduced-motion:reduce){.dbdir-page[data-view=indication] .dbdir-acc-head,.dbdir-page[data-view=indication] .dbdir-scroller .dbdir-row{animation:none}}.dbdir-page[data-view=size] .dbdir-card{animation:.4s ease-out both dbdirFadeIn;animation-delay:calc(min(var(--i,0),15)*45ms);background:var(--dbdir-surface);border:1px solid var(--dbdir-line)}.dbdir-page[data-view=size] .dbdir-card:hover,.dbdir-page[data-view=size] .dbdir-card:focus-within,.dbdir-page[data-view=size] .dbdir-card .dbdir-action:hover,.dbdir-page[data-view=size] .dbdir-card .dbdir-action:focus-visible{border-color:color-mix(in srgb,var(--dbdir-muted)40%,var(--dbdir-line))}.dbdir-page[data-view=size] .dbdir-card:hover .dbdir-card-link,html[data-theme=dark] .dbdir-page[data-view=size] .dbdir-card:hover .dbdir-card-link{color:var(--dbdir-ink)}.dbdir-card-prefix,.dbdir-card:hover .dbdir-card-prefix,.dbdir-page[data-view=size] .dbdir-card:hover .dbdir-card-prefix{color:var(--dbdir-muted);font-weight:500}.dbdir-card-sep{color:color-mix(in srgb,var(--dbdir-muted)45%,transparent);white-space:pre;font-weight:300}#dbdir-results.is-scrolling .dbdir-card,#dbdir-results.is-scrolling .dbdir-row,#dbdir-results.is-scrolling .dbdir-acc-toggle{pointer-events:none}.dbdir-card{--tint-strong:13%;--tint-soft:3%;background:linear-gradient(135deg,color-mix(in srgb,var(--tint,transparent)var(--tint-strong),var(--dbdir-surface))0%,color-mix(in srgb,var(--tint,transparent)var(--tint-soft),var(--dbdir-surface))65%);border:.5px solid color-mix(in srgb,var(--tint,transparent)20%,var(--dbdir-line));flex-direction:column;min-width:0;min-height:100%;padding:1.1rem 1.25rem 1rem;transition:transform .2s,box-shadow .2s,border-color .2s;display:flex;position:relative}.dbdir-card:hover,.dbdir-card:focus-within{border-color:color-mix(in srgb,var(--tint,var(--dbdir-muted))40%,var(--dbdir-line));transform:translateY(-3px);box-shadow:0 12px 28px #24323a17}html[data-theme=dark] .dbdir-card{--tint-strong:16%;--tint-soft:4%}html[data-theme=dark] .dbdir-card:hover,html[data-theme=dark] .dbdir-card:focus-within{box-shadow:0 12px 28px #0006}.dbdir-card.shine{isolation:isolate}.dbdir-card.shine:before{z-index:-1;background:radial-gradient(75% 80% at 100% 0%,color-mix(in srgb,var(--tint,var(--dbdir-muted))14%,transparent),transparent 70%);opacity:1}html[data-theme=dark] .dbdir-card.shine:before{display:none}.dbdir-card.has-notch{padding-top:1.85rem}.dbdir-card-notch{max-width:calc(100% - 2.7rem);color:var(--dbdir-muted);background:color-mix(in srgb,var(--tint,var(--dbdir-muted))20%,var(--dbdir-surface));opacity:.6;white-space:nowrap;text-overflow:ellipsis;border:0;border-radius:0;padding:.1rem .55rem .15rem;font-size:.7rem;line-height:1.35;transition:opacity .15s;position:absolute;top:0;right:0;overflow:hidden}.dbdir-card:hover .dbdir-card-notch,.dbdir-card:focus-within .dbdir-card-notch{opacity:1}html[data-theme=dark] .dbdir-card-notch{background:color-mix(in srgb,var(--tint,var(--dbdir-muted))38%,var(--dbdir-surface))}.dbdir-card-title{margin:0 0 .9rem;font-size:1rem;font-weight:500;line-height:1.35}.dbdir-card-link{color:var(--dbdir-ink);text-decoration:none}.dbdir-card-link:after{content:"";z-index:1;position:absolute;inset:0}.dbdir-card-link:focus-visible{outline:none}.dbdir-card:has(.dbdir-card-link:focus-visible){outline:2px solid var(--dbdir-teal);outline-offset:2px}.dbdir-card-link{transition:color .15s}.dbdir-card:hover .dbdir-card-link{color:color-mix(in srgb,var(--tint,var(--dbdir-ink))85%,#000)}html[data-theme=dark] .dbdir-card:hover .dbdir-card-link{color:color-mix(in srgb,var(--tint,var(--dbdir-ink))55%,#fff)}.dbdir-card-foot{align-items:center;gap:.5rem;margin-top:auto;display:flex}.dbdir-trials{border:1px solid var(--dbdir-line);color:var(--dbdir-muted);white-space:nowrap;border-radius:4px;flex:none;align-items:baseline;gap:.25rem;margin-right:auto;padding:.25rem .55rem;font-size:.75rem;line-height:1.3;display:inline-flex}.dbdir-trials.dbdir-action{max-width:none}.dbdir-info .bi{align-self:center;margin-right:.1rem;font-size:.75rem}.dbdir-trials strong{font-weight:inherit;color:inherit;font-variant-numeric:tabular-nums}.dbdir-action{z-index:2;border:1px solid var(--dbdir-line);min-width:0;max-width:13rem;color:var(--dbdir-muted);cursor:pointer;background:0 0;border-radius:4px;flex:none;align-items:center;gap:.35rem;padding:.25rem .55rem;font-size:.75rem;line-height:1.3;text-decoration:none;transition:color .15s,border-color .15s,background-color .15s;display:inline-flex;position:relative}.dbdir-action:hover,.dbdir-action:focus-visible{color:var(--dbdir-ink);border-color:var(--dbdir-muted);outline:none}.dbdir-copy{flex:0 auto}.dbdir-docs{gap:.3rem}.dbdir-docs .bi{font-size:.68rem}.dbdir-action code{color:inherit;font-family:inherit;font-size:inherit;white-space:nowrap;text-overflow:ellipsis;overflow:hidden}.dbdir-action.is-copied{color:var(--dbdir-ink);border-color:var(--dbdir-muted)}.dbdir-acc,.dbdir-modal-box{--tint:var(--dbdir-muted)}.dbdir-page[data-view=indication] .dbdir-chip{--tint:var(--dbdir-muted)!important}.dbdir-acc-toggle,html[data-theme=dark] .dbdir-acc-toggle{background:color-mix(in srgb,var(--dbdir-muted)6%,var(--dbdir-surface))}.dbdir-acc-toggle:hover .dbdir-acc-title,html[data-theme=dark] .dbdir-acc-toggle:hover .dbdir-acc-title{color:var(--dbdir-ink)}.dbdir-row-go{vertical-align:middle;color:var(--bs-primary);opacity:0;margin-left:.35rem;font-size:.8rem;line-height:1;transition:opacity .15s,transform .15s;display:inline-block;transform:translate(-3px)}html[data-theme=dark] .dbdir-row-go{color:color-mix(in srgb,var(--bs-primary)65%,#fff)}.dbdir-row:hover .dbdir-row-go,.dbdir-row:has(.dbdir-row-link:focus-visible) .dbdir-row-go{opacity:1;transform:none}@media (prefers-reduced-motion:reduce){.dbdir-row-go{transition:none;transform:none}}.dbdir-row:hover .dbdir-row-link,html[data-theme=dark] .dbdir-row:hover .dbdir-row-link{color:var(--dbdir-ink)}html[data-theme=dark] .dbdir-page[data-view=indication]{--dbdir-accent:#5ebabd;--dbdir-accent-2:#2e86b2}html[data-theme=dark] .dbdir-page[data-view=indication] .dbdir-acc-list{--dbdir-link:color-mix(in srgb,var(--dbdir-accent)45%,var(--dbdir-chip-bg))}html[data-theme=dark] .dbdir-page[data-view=indication] .dbdir-row:nth-child(2n){background:color-mix(in srgb,var(--dbdir-accent-2)9%,var(--dbdir-surface))}html[data-theme=dark] .dbdir-page[data-view=indication] .dbdir-info .bi{color:color-mix(in srgb,var(--dbdir-accent)80%,#fff)}html[data-theme=dark] .dbdir-page[data-view=indication] .dbdir-row-label,html[data-theme=dark] .dbdir-page[data-view=indication] .dbdir-acc-count{color:color-mix(in srgb,var(--dbdir-accent)30%,var(--dbdir-muted))}html[data-theme=dark] .dbdir-page[data-view=indication] .dbdir-acc-toggle{background:color-mix(in srgb,var(--dbdir-accent-2)10%,var(--dbdir-surface))}html[data-theme=dark] .dbdir-page[data-view=indication] .dbdir-acc{border-color:color-mix(in srgb,var(--dbdir-accent)18%,var(--dbdir-line))}@media (width>=1200px){html[data-theme=dark] .dbdir-page[data-view=indication] .dbdir-acc-list{background:color-mix(in srgb,var(--dbdir-accent-2)6%,var(--dbdir-surface));border-color:color-mix(in srgb,var(--dbdir-accent)16%,var(--dbdir-line));border-top:1px solid color-mix(in srgb,var(--dbdir-accent)16%,var(--dbdir-line));margin-top:2rem;padding-top:2rem}html[data-theme=dark] .dbdir-page[data-view=indication] .dbdir-acc-list .dbdir-acc-toggle{background:0 0}html[data-theme=dark] .dbdir-page[data-view=indication] .dbdir-acc-list .dbdir-acc-toggle:hover{background:color-mix(in srgb,var(--dbdir-accent)9%,transparent)}html[data-theme=dark] 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#141c2040}.dbdir-modal-close{width:2rem;height:2rem;color:var(--dbdir-muted);cursor:pointer;background:0 0;border:0;border-radius:50%;justify-content:center;align-items:center;font-size:.9rem;display:inline-flex;position:absolute;top:1rem;right:1rem}.dbdir-modal-close:hover{color:var(--dbdir-ink);background:color-mix(in srgb,var(--dbdir-muted)12%,transparent)}.dbdir-modal-close:focus-visible{outline:2px solid var(--dbdir-teal);outline-offset:1px}.dbdir-modal-desc{color:var(--dbdir-muted);margin:0;padding:1.5rem 3.5rem 1.35rem 1.5rem;font-size:.95rem;line-height:1.6}.dbdir-modal-foot{border-top:.5px solid var(--dbdir-line);align-items:center;gap:1rem;padding:1rem 1.5rem 1.25rem;display:flex}.dbdir-modal-meta{flex:auto;align-items:center;gap:.5rem;min-width:0;display:flex}.dbdir-modal-meta .dbdir-trials{margin-right:0}.dbdir-modal-open{background:var(--bs-primary);color:#fff;border-radius:4px;flex:none;align-items:center;gap:.4rem;margin-left:auto;padding:.35rem 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var(--dbdir-line);grid-template-columns:1fr;align-items:center;gap:1.5rem;margin-top:2rem;padding:1.75rem;display:grid}@media (width>=992px){.dbdir-access{grid-template-columns:1fr 1fr;gap:2.5rem;padding:2.25rem 2.5rem}}.dbdir-access h2{color:var(--dbdir-ink);margin:0 0 .5rem;font-size:1.3rem;font-weight:700}.dbdir-access p{color:var(--dbdir-muted);margin:0 0 1rem;font-size:.93rem}.dbdir-access p code{color:inherit;background:0 0;padding:0;font-size:.92em}.dbdir-access p a{color:var(--dbdir-blue);text-decoration:none}.dbdir-access p a:hover{text-decoration:underline}.dbdir-access p a code{color:inherit}html[data-theme=dark] .dbdir-access p a{color:var(--dbdir-teal)}.dbdir-access-links{flex-wrap:wrap;gap:.5rem 1.25rem;font-size:.9rem;display:flex}.dbdir-access-links a{color:var(--dbdir-muted);align-items:center;gap:.35rem;font-weight:500;text-decoration:none;transition:color .15s;display:inline-flex}.dbdir-access-links a:hover,.dbdir-access-links a:focus-visible{color:var(--dbdir-blue);text-decoration:underline}.dbdir-access-links a .bi{font-size:1rem;line-height:1}.dbdir-access-r{color:currentColor;flex:none;width:1rem;height:1rem;display:block}html[data-theme=dark] .dbdir-access-links a:hover,html[data-theme=dark] .dbdir-access-links a:focus-visible{color:var(--dbdir-teal)}.dbdir-code-wrap{min-width:0;position:relative}.dbdir-code{color:#cdd3d8;border:1px solid var(--dbdir-line-solid);background:#2b2b2d;border-radius:0;margin:0;padding:1.1rem 3.25rem 1.1rem 1.25rem;font-size:.84rem;line-height:1.6;overflow-x:auto}.dbdir-code code,.dbdir-code code.hljs{font-size:inherit;line-height:inherit;color:inherit;display:block;overflow:visible;background:0 0!important;padding:0!important}.dbdir-copy-btn{cursor:pointer;opacity:0;border:0;border-radius:0;padding:.5rem .7rem;font-size:.8rem;transition:opacity .15s;position:absolute;top:0;right:0}.dbdir-code-wrap:hover .dbdir-copy-btn,.dbdir-copy-btn:focus-visible{opacity:1}.dbdir-copy-btn:focus-visible{outline:2px solid var(--dbdir-teal);outline-offset:1px}.dbdir-code-wrap:hover .dbdir-copy-btn.is-copied,.dbdir-copy-btn.is-copied{opacity:0;pointer-events:none}.dbdir-copy-ok{color:var(--dbdir-teal);background:#1f2a30;border-radius:0;padding:.3rem .65rem;font-size:.8rem;position:absolute;bottom:0;right:0}.dbdir-copy-ok[hidden]{display:none!important}.dbdir-sr-only{clip:rect(0,0,0,0)!important;white-space:nowrap!important;border:0!important;width:1px!important;height:1px!important;margin:-1px!important;padding:0!important;position:absolute!important;overflow:hidden!important}.dbdir-skeleton{grid-template-columns:repeat(auto-fill,minmax(18rem,1fr));gap:1.25rem;display:grid}.dbdir-skeleton span{background:linear-gradient(90deg,var(--dbdir-surface)0%,color-mix(in srgb,var(--dbdir-line)60%,var(--dbdir-surface))50%,var(--dbdir-surface)100%);border:1px solid var(--dbdir-line);background-size:200% 100%;height:11rem;animation:1.4s ease-in-out infinite dbdirShimmer}@keyframes dbdirShimmer{0%{background-position:100% 0}to{background-position:-100% 0}}@media (prefers-reduced-motion:reduce){.dbdir-search-dock .dbdir-search,.dbdir-modal[open],.dbdir-acc.is-open .dbdir-acc-panel,.dbdir-connector path.is-drawing{animation:none}.dbdir-acc-panel,.dbdir-acc-inner,.dbdir-acc-chev{transition:none}.dbdir-card,.dbdir-chip,.dbdir-skeleton span{transition:none;animation:none}.dbdir-card:hover,.dbdir-card:focus-within{transform:none}}@media (width<=575.98px){.dbdir-page .container{padding-left:1rem;padding-right:1rem}.dbdir-card{padding:1.1rem 1.1rem .9rem}.dbdir-access{padding:1.35rem}.dbdir-toolbar-inner{flex-wrap:wrap;row-gap:.6rem}.dbdir-view{order:-1;width:100%}.dbdir-view button{min-width:0}.dbdir-chips{flex:100%}}